HSV oncolytic vectors
  • After intratumoral injection virus replication is exquisitely restricted to tumor.
  • Enhanced tumor kill by expression of:
Enzymes for prodrug therapy
Transporters for specific uptake of toxic compounds
Oncogene silencing by antisense and siRNA
Oncogene silencing by intrabodies
Tumor suppressor genes
Cancer vaccine and immune system modulators
Virus expressing antisense RNA to an oncogene improves tumor kill in mice compared to viral vector alone

Days post injection
Tumor cells infected with an oncolytic HSV expressing antisense RNA + gfp
DAPI GFP DAPI/GFP