HSV gene therapy vectors
- Replication defective virus can access
numerous different cell types
- High level of transgene expression using constitutive, tissue specific or switchable promoters
Proinsulin
expression in Vero, HuH7, AtT20 cells infected with either vector alone
or vector+preproinsulin transgene
- Trackable transgene expression using -IRES-gfp
- Diverse transgenes can be expressed including:
- Comparison of proinsulin, insulin and C-peptide levels following infection of the neuroendocrine cell line AtT20 with either vector alone or expressing preproinsulin transgene.
